Effect of Coriandrum sativum L. seeds on blood glucose in streptozotocin-induced diabetic rats

Diabetes mellitus is considered a serious endocrine syndrome. The prevalence of diabetes mellitus in the general population is greater than 6%. Many herbal medicines have been recommended for the treatment of diabetic. The present study was carried out to investigate the effect of the alcoholic extract seeds of Coriandrum sativum L. on blood glucose in streptozotocin-induced diabetic rats. The alcoholic extract was intraperitoneally administrated animals and the levels of blood glucose were measured before and 1.5, 3 and 5 h after extract administration. The extract produced hypoglycemic effect in diabetic animals. In conclusion, our results have shown that alcoholic extract of Coriandrum sativum seeds possess a hypoglycaemic effect on streptozotocin-induced hyperglycaemic rats intraperitoneally. Thus, the folk use of this plant may be validated by this study. However, controlled clinical trials will be required to confirm its hypoglycaemic action and general safety.